Abstract
TSPO as a target for treatments of diseases, including neuropathological disorders.
Highlights
Recent knockout studies in mice have heightened interest in the 18-kDa translocator protein (TSPO) as a target for drug treatment of various diseases.[1]
TSPO function may be inconspicuous in health, various studies have suggested
It was found that relatively small (~400 molecular weight) tricyclic compounds based on the bicyclic quinazoline as a scaffold can be used to regulate the functions of the TSPO.[6]
Summary
Recent knockout studies in mice have heightened interest in the 18-kDa translocator protein (TSPO) as a target for drug treatment of various diseases.[1]. It was found that relatively small (~400 molecular weight) tricyclic compounds based on the bicyclic quinazoline as a scaffold can be used to regulate the functions of the TSPO.[6]
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