Abstract
There are several facts suggesting that the first step in the biosynthesis of 5-hydroxytryptamine, the formation of 5-hydroxytryptophan by tryptophan hydroxylation, may occur in brain: 1. 1. There is a rapid turnover of 5-hydroxytryptamine in brain ( Udenfriend and Weissbach, 1958); 2. 2. 5-hydroxytryptamine does not freely enter the brain from the circulation ( Udenfriend, Weissbach and Bogdanski, 1957); 3. 3. Intracerebral but not intraperitoneal injections of DL -[3- 14C] tryptophan produces labelling of brain 5-hydroxytryptamine ( Gal, Marshall and Poczik, 1963). It has now been possible to demonstrate enzymic tryptophan hydroxylation in isolated brain tissue.
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