Abstract

In biomedical research lack of trust is seen as a great threat that can severely jeopardise the whole biomedical research enterprise. Practices, such as informed consent, and also the administrative and regulatory oversight of research in the form of research ethics committees and Institutional Review Boards, are established to ensure the protection of future research subjects and, at the same time, restore public trust in biomedical research. Empirical research also testifies to the role of trust as one of the decisive factors in research participation and lack of trust as a barrier for consenting to research. However, what is often missing is a clear definition of trust. This paper seeks to address this gap. It starts with a conceptual analysis of the term trust. It compares trust with two other related terms, those of reliance and trustworthiness, and offers a defence of Baier’s attribute of ‘good will’ a basic characteristic of trust. It, then, proceeds to consider trust in the context of biomedical research by examining two questions: First, is trust necessary in biomedical research?; and second, do increases in regulatory oversight of biomedical research also increase trust in the field? This paper argues that regulatory oversight is important for increasing reliance in biomedical research, but it does not improve trust, which remains important for biomedical research. It finishes by pointing at professional integrity as a way of promoting trust and trustworthiness in this field.

Highlights

  • In biomedical research lack of trust is seen as a great threat that can severely jeopardise the whole biomedical research enterprise (Kass et al 1996; Mastroianni 2008)

  • Empirical research testifies to the role of trust as one of the decisive factors in research participation and lack of trust as a barrier for consenting to research (Sugarman et al 1998; CorbieSmith et al 1999; de Melo-Martın and Ho 2008; Marsh et al 2008; Slegers et al 2015)

  • The paper argues that trust is, important for biomedical research, and it finishes by pointing at professional integrity as a way of promoting trust and trustworthiness in this field

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Summary

Introduction

In biomedical research lack of trust is seen as a great threat that can severely jeopardise the whole biomedical research enterprise (Kass et al 1996; Mastroianni 2008). Community engagement has been promoted as the most effective way of building trust relationships with participants and communities, and for this reason, is increasingly seen as essential requirement of ethical research (Marshall and Rotimi 2001).

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