Abstract
It is widely accepted that oral squamous cell carcinoma (OSCC) is a major contributor to the incidence and mortality of neck and head cancer. Tropomyosin-1 (TPM1), which is expressed at a low level, has been considered a prominent tumor-suppressing gene in a variety of solid tumors, although the precise mechanism of the TPM1 gene in OSCC progression remains unknown. We found that TPM1 expression levels decreased in OSCC patients and OSCC cell lines. The overall and cancer-specific survival of patients who exhibited low TPM1 levels were inferior to those of patients who had high TPM1 levels. It was also found that OSCC patients who suffered from disease stageⅠ-Ⅱ were more likely to have an up-regulated TPM1 expression level, and OSCC patients with lymph node metastasis had a higher probability of exhibiting reduced TPM1 expression. We show that overexpression of TPM1 can promote cell apoptosis and inhibit migration. Our results suggest that TPM1 can suppress tumors in OSCC, and the TPM1 expression level is related to OSCC patient prognosis.
Highlights
Oral squamous cell carcinoma (OSCC) causes a portion of head and neck carcinomas, which may present as a primary lesion in any portion of the oropharynx or oral cavity
Surgery Department of Xiangya Stomatological Hospital, Central South University from April 2013 to April 2014. Another batch of specimens, including 87 OSCC tissue specimens, which were fixed by formalin and embedded by paraffin, and 16 OSCC adjacent normal epithelium specimens, 87 OSCC patients diagnosed with tongue carcinoma, mouth floor carcinoma, mouth mucous membrane carcinoma, gingival carcinoma and oropharyngeal carcinoma were acquired from the Oral Pathology Department of Xiangya Hospital, Central South University from January 2010 to March 2011
RT-PCR and western blotting were utilized for determining the TPM1 levels in OSCC cell lines (SCC15, SCC25) and a normal epithelium cell line (HaCat)
Summary
Oral squamous cell carcinoma (OSCC) causes a portion of head and neck carcinomas, which may present as a primary lesion in any portion of the oropharynx or oral cavity It was revealed by the International Agency for Research on Cancer that, in 2012, the number of new cases of OSCC and related deaths was 300,373 and 145,353, respectively[1]. TPM1 expression and function in the OSCC during last two decades[2,3,4,5], and the long-term survival rate of OSCC patients remains unfavorable New therapies, such as molecular therapies, for OSCC that can provide additional insights in disease screening and treatment selection are urgently needed, the precise mechanisms of OSCC progression are still unclear
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