Abstract
Two undescribed compounds, 3β,7β-dihydroxy-24-methylenelanosta-8-ene-11-one (1) and neolignane deightonin (4) were isolated from the aerial parts of Euphorbia deightonii Croizat together with six known compounds, namely, kansenone (2), euphorbol-7-one (3), dehydrodiconiferyl diacetate (5), marylaurencinol D (6), scoparon (7), and 3,4,3′-tri-O-methylellagic acid (8). The structures of the isolated compounds were determined by HRESIMS, 1D (1H, 13C JMOD) and 2D NMR (HSQC, HMBC, 1H–1H COSY, NOESY) spectroscopic analysis, and by comparison of the assignments with literature data. The anti-herpes simplex virus type-2 activity of the isolated compounds were investigated by qRT-PCR assay on Vero cells after determining cytotoxic concentration 50% (CC50). Compounds 1, 3, 4, and 7 exhibited inhibitory effects with respective IC50 values of 7.05, 2.42, 11.73, and 0.032 µM. Scoparon (7) showed the strongest anti-HSV activity with a selectivity index of 10.93.
Highlights
The herpes simplex virus (HSV) causes one of the most common viral infections in humans, in whom infection causes a variety of disorders ranging from mild to severe diseases, and in certain cases life-threatening illness
The present paper describes the isolation and structure elucidation of two novel and six known compounds from E. deightonii, together with the investigation of their anti-HSV-2 activity
Large quantity of the fresh aerial parts of E. deightonii was collected from Zaria city, Kaduna State of Nigeria
Summary
The herpes simplex virus (HSV) causes one of the most common viral infections in humans, in whom infection causes a variety of disorders ranging from mild to severe diseases, and in certain cases life-threatening illness. Two different types of HSV are distinguished: HSV-1 and HSV-2; the former is primarily responsible for oral herpes cases, while the latter causes genital herpes. It has been estimated that more than two-thirds of the population under the age of 50 is infected with either HSV-1 or HSV-2 Eradication of both HSV-1 and HSV-2 from the body is not possible, as they cause lifelong infections. Most of the herpes infections are asymptomatic, some may experience painful and blistering sores, as well as flu-like symptoms, such as enlarged lymph nodes, tiredness, headache, etc. An effective antiHSV vaccine is yet to be developed; in the meantime, two medications—acyclovir and valacyclovir—are capable of alleviating the symptoms of the infection [2]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
