Abstract
ABSTRACT Introduction CD38 and BCMA are proteins expressed at high levels in multiple myeloma cells, so they are targets for the development of mono- or multispecific antibodies. Areas covered patent US20240132615 describes anti-CD3/BCMA/CD38 trispecific antibodies and a method of treating relapsed/refractory multiple myeloma pharmaceutically. In vitro and preclinical results show that anti-CD3/BCMA/CD38 trispecific antibodies have stronger binding affinity and killing potency compared to daratumumab, isatuximab, and teclistamab antibodies. Expert opinion the trispecific structure and a silenced Fc is a pharmaceutical advantage of the anti-CD3/BCMA/CD38 antibody for the treatment of relapsed or refractory multiple myeloma.
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