Abstract
A 10-year-old girl with congenital hypothyroidism was maintained for many years on a regimen of desiccated thyroid, 150 mg daily. Estimation of serum thyroxine (T 4 ), free T 4 , and triiodothyronine (T 3 ) uptake levels indicated a euthyroid state. Imipramine hydrochloride (Tofranil), 25 mg daily, was added for control of enuresis. Severe clinical thyrotoxicosis developed. The T 4 level was 9.2μg/100 ml. At this time, imipramine therapy was discontinued and the patient again became clinically euthyroid. Imipramine has demonstrable sympathomimetic activity. Circulating T 3 levels were estimated after discontinuing imipramine treatment and were greatly elevated. We suggest that this child may have had clinically unrecognizable T 3 thyrotoxicosis shown by the addition of sympathomimetic medication. Determination of T 4 , free T 4 , and T 3 uptake may not be sufficient to adequately define the thyroid status of patients receiving thyroid.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
