Abstract
Objective Insulin resistance (IR) is closely associated with metabolic profiles, including obesity and dyslipidemia. The aim of the present study was to examine how lipid profiles were associated with IR in nonobese middle-aged and elderly Chinese population. Methods This cross-sectional study included 1608 subjects. IR was defined by homeostasis model assessment of insulin resistance (HOMA-IR) of at least 2.5. Results In nonobese subjects (body mass index (BMI) < 25 kg/m2, n = 996), triglyceride (TG) to high-density lipoprotein cholesterol (HDL-C) ratio (odds ratio (OR) = 1.43, 95% confidence interval (CI) 1.13–1.81, P=0.003) was an independent risk factor for IR. The best marker for predicting IR in nonobese subjects was TG/HDL-C ratio with the areas under the receiver operating characteristic curves (AUC) of 0.73 (P < 0.001). The optimal cut-off point to identifying IR for TG/HDL-C ratio was ≥1.50 in the nonobese population. Other markers like BMI, TG, and total cholesterol (TC)/HDL-C also had acceptable discriminatory power for predicting IR in nonobese population (AUC ≥ 0.7 and P < 0.001). BMI had the highest AUC of 0.647 (P < 0.001) after being adjusted, but it was not effective enough to predict IR in obese subjects (BMI ≥ 25.0, n = 612). Conclusions The TG/HDL-C ratio may be the best reliable marker for predicting IR in the nonobese middle-aged and elderly Chinese population.
Highlights
Type 2 diabetes mellitus (T2DM) is a worldwide growing health problem
The standard methods of measuring Insulin resistance (IR) include the glucose clamp, the modified insulin suppression test, and the homeostasis model assessment of insulin resistance (HOMA-IR) [2,3,4], but these tests are not routinely measured in most clinical practices owing to the time and cost involved. us, early identification of IR by using simple and inexpensive method is essential for preventing T2DM
McLaughlin et al first proposed that TG/highdensity lipoprotein cholesterol (HDL-C) ratio could be used to identify overweight individuals who are insulin-resistant in 2003 [7]. ereafter, several studies have reported that TG/HDL-C ratio could be a simple marker of IR [3, 4, 8, 9]
Summary
IR and impaired β-cell function are considered as the primary defects in T2DM [1]. Ereafter, several studies have reported that TG/HDL-C ratio could be a simple marker of IR [3, 4, 8, 9]. E TG/ HDL-C ratio may be a good marker to identify insulinresistant individuals of Aboriginal, Chinese, and European, but not South Asian population [3]. Previous studies in Chinese population have suggested that TG/HDL-C ratio could be a good predictor of IR [4, 8]. Is study aims to develop a simple predictive marker as a clinical tool for the evaluation of IR in nonobese middle-aged and elderly Chinese population and to further explore the optimal cut-offs The relationship between TG/HDL-C ratio and IR in International Journal of Endocrinology nonobese middle-aged and elderly people remains unknown. is study aims to develop a simple predictive marker as a clinical tool for the evaluation of IR in nonobese middle-aged and elderly Chinese population and to further explore the optimal cut-offs
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