Abstract
BackgroundThe aim of the present study was to examine how lipid profiles are associated with insulin resistance in Japanese community-dwelling adults.MethodsThis cross-sectional study included 614 men aged 58 ± 14 (mean ± standard deviation; range, 20-89) years and 779 women aged 60 ± 12 (range, 21-88) years. The study sample were 1,042 (74.8%) non-obese (BMI < 25.0 kg/m2) and 351 (25.2%) overweight (BMI ≥ 25 kg/m2) subjects. Insulin resistance was defined by homeostasis model assessment of insulin resistance (HOMA-IR) of at least 2.5. The areas under the curve (AUC) of the receiver operating characteristic curves (ROC) were used to compare the power of these serum markers.ResultsIn non-obese subjects, the best marker of insulin resistance was low-density lipoprotein cholesterol (LDL-C)/high-density lipoprotein cholesterol (HDL-C) ratio of 0.74 (95% confidence interval (CI), 0.66-0.80). The HDL-C, triglyceride (TG)/HDL-C ratio, and non-HDL-C also discriminated insulin resistance, as the values for AUC were 0.31 (95% CI, 0.24-0.38), 0.69 (95% CI, 0.62-0.75) and 0.69 (95% CI, 0.62-0.75), respectively. In overweight subjects, the AUC for TG and TG/HDL-C ratio were 0.64 (0.58-0.71) and 0.64 (0.57-0.70), respectively. The optimal cut-off point to identifying insulin resistance for these markers yielded the following values: TG/HDL-C ratio of ≥1.50 and LDL-C/HDL-C ratio of ≥2.14 in non-obese subjects, and ≥2.20, ≥2.25 in overweight subjects. In non-obese subjects, the positive likelihood ratio was greatest for LDL-C/HDL-C ratio.ConclusionIn non-obese Japanese adults, LDL-C/HDL-C ratio may be the best reliable marker of insulin resistance.
Highlights
The aim of the present study was to examine how lipid profiles are associated with insulin resistance in Japanese community-dwelling adults
High-density lipoprotein cholesterol (HDLC) [9,10], and total cholesterol (T-C)/HDL-C are independently associated with insulin resistance and risk factors of cardiovascular disease (CVD) [11]
Systolic blood pressure (SBP), diastolic blood pressure (DBP), T-C, TG, LDL-C, TG/HDL-C ratio, non-HDL-C, LDL-C/HDL-C ratio, and uric acid were significantly higher in subjects with a BMI ≥ 25.0 kg/m2, but age, HDL-C and serum high molecular weight (HMW) adiponectin were
Summary
The aim of the present study was to examine how lipid profiles are associated with insulin resistance in Japanese community-dwelling adults. Several large-scale studies have shown that overweight people, defined on the basis of a high BMI, increases the risk of hypertension, dyslipidemia, diabetes and. High-density lipoprotein cholesterol (HDLC) [9,10], and total cholesterol (T-C)/HDL-C are independently associated with insulin resistance and risk factors of CVD [11]. In Japanese communitydwelling persons, there are few studies to demonstrate a relationship between lipid profiles and insulin resistance, categorized by BMI. We took advantage of the large representative sample of Japanese adults who participated at the time of their annual health examination. We investigated how lipid profiles were associated with insulin resistance in healthy Japanese adults. We used cross-sectional data from community-dwelling participants without clinical diabetes
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