Abstract
BackgroundHypertriglyceridemia, insulin resistance and hyperglycemia are risk factors for atherosclerosis in type 2 diabetes. Angiopoietin-like protein 8 (ANGPTL8) is a newly identified liver-derived hormone related to these risk factors. Hence, we aimed to explore the correlations between serum levels of ANGPTL8 and subclinical atherosclerosis in type 2 diabetes.MethodsWe measured serum ANGPTL8, blood lipids, blood glucose, common carotid artery Intima-Media Thickness (c-IMT) and calculated homeostasis model assessment of insulin resistance in (1) control subjects (n = 100), (2) type 2 diabetic patients without subclinical atherosclerosis (n = 100), and (3) type 2 diabetic patients with subclinical atherosclerosis (n = 100).ResultsSerum levels of ANGPTL8 and triglyceride (TG) were significantly increased in type 2 diabetic patients with subclinical atherosclerosis as compared with type 2 diabetic patients without subclinical atherosclerosis and control subjects (P < 0.001). ANGPTL8 was positively associated with age, TG, diabetes duration, and c-IMT in type 2 diabetes. Logistic regression analysis revealed that ANGPTL8 had higher odds of having subclinical atherosclerosis [odds ratio (OR) 2.90, 95% confidence interval (CI) 1.48–5.70, P = 0.002] in type 2 diabetes. Mediation analysis indicated that TG acted as a partial mediator in the relationship between ANGPTL8 and c-IMT.ConclusionsTG partially mediates the positive relationship between ANGPTL8 and c-IMT. Our data provide the first evidence for a strong link between ANGPTL8 and subclinical atherosclerosis, suggesting ANGPTL8 to be a new biomarker for subclinical atherosclerosis in type 2 diabetes.
Highlights
Hypertriglyceridemia, insulin resistance and hyperglycemia are risk factors for atherosclerosis in type 2 diabetes
Our data indicated that statin use, TG, duration of diabetes, carotid artery Intima-Media Thickness (c-IMT) and Angiopoietin-like protein 8 (ANGPTL8) in type 2 diabetic patients with subclinical atherosclerosis had a significant increase than in control subjects with normal glucose tolerance (NGT) and type 2 diabetic patients without subclinical atherosclerosis, whereas leisure-time physical activity had a significant decrease in type 2 diabetic patients with subclinical atherosclerosis than in control subjects
No significant correlations were found between ANGPTL8 and SBP, DBP, total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C), fasting plasma glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), HbA1c in all three groups
Summary
Hypertriglyceridemia, insulin resistance and hyperglycemia are risk factors for atherosclerosis in type 2 diabetes. Angiopoietin-like protein 8 (ANGPTL8) is a newly identified liver-derived hormone related to these risk factors. A metaanalysis study by Yue et al revealed that type 2 diabetic patients had higher circulating levels of ANGPTL8 compared with those without type 2 diabetes, suggesting a. We were motivated to hypothesize that increased circulating levels of ANGPTL8 might be positively associated with common carotid artery Intima-Media Thickness (c-IMT) and serve as a novel biomarker for atherosclerosis in type 2 diabetes. No study has ever evaluated the association between circulating levels of ANGPTL8 and c-IMT or considered the possibility of identifying ANGPTL8 as a risk biomarker for subclinical atherosclerosis in type 2 diabetes
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