Abstract
Calves inoculated intranasally with infectious bovine rhinotracheitis (IBR) virus were necropsied 12, 15, 30, 57 and 98 days after inoculation. Tissues were subjected to histopathological, fluorescent-antibody tracing and viral examinations. The significant histopathological changes were a non-suppurative inflammation of the bilateral trigeminal ganglia and the central nervous system. Bilateral trigeminal ganglionitis was associated with the proliferation of neuroglial cells. In the central nervous system, non-suppurative encephalitic changes were found almost exclusively in the rhombencephalon. Brain lesions were localized in the inoculated side and mostly in the main sensory and spinal tract nuclei of the trigeminal nerve in the medulla oblongata. These lesions existed until 98 days after inoculation. IBR virus was recovered from the cerebrum, medulla oblongata and trigeminal ganglion of calves necropsied at 12 and 15 days after inoculation.
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