Abstract

This second article in the series on antidepressants reviews the tricyclic antidepressants (TCAs). After observing that chlorpromazine, an antihistamine drug, also had neuroleptic qualities, imipramine, a derivative of this pioneering compound, was introduced to the pharmaceutical market in the 1960s. Using the monoamine theory of depression to help conceptualize the mechanism of action of this class of antidepressants, this article will consider the ADME properties of TCAs before discussing the vulnerable populations requiring caution in prescribing. The alternative therapeutic uses of TCAs will also be highlighted.

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