Abstract
TRIB3-P62 interaction, diabetes and autophagy.
Highlights
Tribbles 3 (TRIB3) is a member of Tribbles homolog family which belongs to the pseudokinase
We demonstrate that metabolic stresses enhance the TRIB3-mediated malignancy-promoting actions [4]
TRIB3 directly interacts with autophagic receptor P62 to interfere with the binding of P62 to LC3 and to ubiquitinated proteins, which results in the defect of P62-mediated selective autophagy and autophagy-dependent clearance of ubiquitinated proteins, and subsequently bothers the ubiquitin-proteasomedependent degradation
Summary
Tribbles 3 (TRIB3) is a member of Tribbles homolog family which belongs to the pseudokinase. We demonstrate that metabolic stresses enhance the TRIB3-mediated malignancy-promoting actions [4]. Interrupting the TRIB3/ P62 interaction by a P62-derived α-helical peptide inhibits tumor initiation, growth and metastasis, and increases animal survival through restoring the selective autophagy degradation and accelerating the ubiquitin proteasome system (UPS) clearance of the tumor-promoting factors.
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call