Triazole tethered organosilane based fluorescent sensor as a logic gate operation for selective detection of Sn2+ ions: A potent Cyclooxygenase-2 inhibitor

Abstract

In recent years, the development of a probe for tin ions has gained significant attention due to their relevance in environmental, industrial, and biological contexts. To address this, an imidazole-based fluorescent sensor called BO was designed and synthesized using the click methodology. The characterization of BO was carried out using NMR spectroscopy and mass spectrometry techniques. The fluorescence of BO exhibits remarkable selectivity and sensitivity towards Sn2+ ions, even in the presence of other metal ions. This increase in fluorescence is attributed to the suppression of the PET process upon interaction with Sn2+ ions. Notably, the detection limits for Sn2+ ions using BO in this study are much lower than the drinking water recommendations set by the WHO. Furthermore, it was observed that compound BO displays reversible behaviour towards Sn2+ ions through the formation of the sodium salt of CH3COO–, suggesting its potential application in the construction of a molecular logic gate. Additionally, molecular docking experiments with the Cyclooxygenase-2 (COX-2) protein provided further insights into the potential of BO in this regard.