Triazine Compound as Copolymerized Antibacterial Agent in Adhesive Resins.

Priscila Raquel Schiroky,Fabrício Aulo Ogliari,Fabrício Mezzomo Collares,Susana Maria Werner Samuel,Isadora Martini Garcia,Vicente Castelo Branco Leitune

doi:10.1590/0103-6440201701346

Abstract

The aim of this study was to formulate and evaluate an experimental adhesive resin with the addition of 1,3,5-triacryloylhexahydro-1,3,5-triazine at different concentrations. Experimental adhesive resins were obtained by mixing 50% wt bisphenol A glycol dimethacrylate (BisGMA), 25% wt triethylene glycol dimethacrylate (TEGDMA), 25% wt 2-hydroxyethyl methacrylate (HEMA) and photoinitiator system. The triazine compound was added in 1, 2.5 and 5% wt to a base adhesive resin and one group remained with no triazine as control group. The experimental adhesive resins were analyzed for antibacterial activity (n=3), degree of conversion (n=3) and softening in solvent (n=3). Data distribution was evaluated by Kolmogorov-Smirnov test, paired t test, one-way ANOVA and Tukey's with a 0.05 level of significance. All groups with added triazine compound showed antibacterial activity against Streptococcus mutans (p<0.05). All groups achieved more than 70% degree of conversion, but there was no difference in this chemical property (p>0.05). The initial Knoop hardness was higher in 2.5 and 5% wt groups (p<0.05) and both groups present lower percentage variation of Knoop hardness after solvent degradation. The present study formulated an antibacterial adhesive resin with a non-releasing agent able to copolymerize with the comonomeric blend, improving the restorative material's properties.

Highlights

The longevity of tooth restorations depends on many factors, like the patient-related variables [1], the technique-sensitive procedure [2] and aspects related to the materials’ properties [3,4]
All adhesives with this compound presented antibacterial activity and the resistance to solvent degradation improved from 2.5% wt antibacterial monomer addition
The experimental adhesive resins containing the triazine compound inhibited Streptococcus mutans growth in all three concentrations (1%, 2.5% and 5%), reducing colony forming units (CFUs) compared to the positive and negative controls (p

Summary

Introduction

The longevity of tooth restorations depends on many factors, like the patient-related variables (e.g. bruxism and caries risk) [1], the technique-sensitive procedure [2] and aspects related to the materials’ properties [3,4]. Biofilm accumulation at tooth/restoration interface may lead to recurrent caries, which is responsible for 60% of restoration replacements in the typical dental practice [5]. Adhesive systems with antibacterial and nonantibacterial releasing agents have been proposed to reduce biofilm formation as an attempt to reduce the susceptibility to caries disease [6]. There is no evidence of antibacterial adhesives effectiveness in the prevention of caries disease, they could benefit conservative dental treatments [6]. The incorporation of antibacterial monomers able to copolymerize the methacrylate with the resin matrix has been studied [8,9] to maintain a post-curing antibacterial effect for the adhesive and a reliable cavity seal

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Conclusion