Abstract

Residues of organochlorine pesticides and their metabolites in various human tissues and fluids are Indicative of the total body burden of these chemicals and reflect past and present exposure to them. A national monitoring survey of human adipose tissue collected from the general population has been conducted annually by the EPA National Human Monitoring Program since 1969. Using gas-liquid chromatography, chemical analyses performed on over 9,000 samples of human adipose tissue demonstrated that quantifiable residues of DDT DDE (a DDT analog), beta-benzene hexachloride, heptachlor epoxide, oxychlordane trans-nonachlor, dieldrin, and hexachlorobenzene were contained in most specimens. Lindane (gamma-benzene hexachloride), alpha-benzene hexachloride, and mirex residues were detected at low frequencies. Residues of delta-benzene hexachloride, heptachlor, endrin, aldrin, and certain DDT analogs were not found at limits of detectability of 10 to 20 ppb. Additional analytical procedures were employed to confirm the presence of specific residues.

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