Abstract
Trends in Sample Preparation for the HPLC Determination of Penicillins in Biofluids
Highlights
This approach gives great results in the elaboration of complex biological samples, such as ovarian cyst fluid, plasma, urine and human cerebrospinal fluid.[2325] Significant benefits include the high extraction efficiency (recovery from 74 to 101.1% based on the matrix and the specific analyte), the extraction and concentration of the analytes in a one single step, the less time consumption (convenient for daily operation), the minimized usage of solvent and the high enrichment
Imprinted solid-phase micro-extraction (MI-Solid-phase microextraction (SPME)) As it was mentioned before, SPME relies on the severance of the desirable analytes between the sample and the stationary phase, which is a fused silica fiber coated with the sorbents
The researchers’ attention was strained to the preparation of silica fibers coated with a Molecularly imprinted polymers (MIPs) [9, 38,39]. As it is commonly declared, sample preparation/pretreatment is the bottleneck of the whole analytical procedure and is fairly considered as the most challenging step
Summary
This approach gives great results in the elaboration of complex biological samples, such as ovarian cyst fluid, plasma, urine and human cerebrospinal fluid.[2325] Significant benefits include the high extraction efficiency (recovery from 74 to 101.1% based on the matrix and the specific analyte), the extraction and concentration of the analytes in a one single step, the less time consumption (convenient for daily operation), the minimized usage of solvent and the high enrichment. The application of DMSPE in various biofluids has all the desirable results, which are in general the high recovery values with low sorbent and organic solvent requirements and fast procedure.
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