Abstract
BackgroundThe aim of this study is to identify the incidence trends of primary and secondary peritoneal surface malignancies in a representative Czech population.MethodsData were obtained from patients registered in the Czech National Cancer Registry between 1979 and 2016. The incidence rates were analyzed between 2012 and 2016. To observe the incidence trends, we analyzed the data from two time periods, 1979–2005 and 2006–2016. The analyzed data included age, sex, and the histological types and primary origins of the malignancies. The Cochrane-Armitage test for linear trends was used for verification of the null hypothesis. The significance level established for hypothesis testing was p = 0.05.ResultsBetween 2012 and 2016, 230 patients with primary peritoneal tumors were identified and divided into the following groups according to their “International Statistical Classification of Diseases and Related Health Problems, 10th revision” codes: malignant neoplasm of specified parts of the peritoneum (C48.1); malignant neoplasm of the peritoneum, unspecified (C48.2); and malignant neoplasm of overlapping sites of the retroperitoneum and peritoneum (C48.8). Moreover, 549 primary tumors of the appendix (C18.1, encompassing all appendiceal malignancies) and 3137 secondary synchronous peritoneal carcinomatoses of other primary origins were documented. The age-adjusted incidence of primary peritoneal tumors in 2012–2016 was 4.36/year/1,000,000 inhabitants. The age-adjusted incidence of synchronous secondary peritoneal malignancies in 2014–2016 was 99.0/year/1,000,000 inhabitants. The diagnoses of primary peritoneal malignancies followed a stable trend between 1979 and 2016. However, the incidences of primary tumors of the appendix increased by 76.7%.ConclusionsThe data produced in our study ought to clarify the status of peritoneal surface malignancies in the Czech Republic, which can lead to improved planning and development of therapeutic interventions as well as physician training.
Highlights
The aim of this study is to identify the incidence trends of primary and secondary peritoneal surface malignancies in a representative Czech population
There were three specific analyses performed: the first was of the age-adjusted incidence of primary peritoneal and appendiceal malignancies between the years 2012 and 2016, the second was of trends of primary peritoneal malignancy diagnoses between the years 1979 and 2016, and the third was of incidences of synchronous secondary peritoneal malignancies diagnosed between 2014 and 2016, when reporting such secondary malignancies to the Cancer Registry (CNCR) became mandatory
Women were diagnosed with tumors of the appendix significantly more frequently than men (59.9% vs. 40.1%; p < 0.001) (Table 2); primary tumors of the appendix most often manifested at a younger age, with 39.2% of the diagnoses occurring in patients 0–49 years of age; a second diagnostic peak was observed among patients 60–69 years of age (24.6%), p < 0.001 (Table 2)
Summary
The aim of this study is to identify the incidence trends of primary and secondary peritoneal surface malignancies in a representative Czech population. Peritoneal surface malignancies are a very heterogeneous group of diseases with generally poor prognosis [1]. They include both primary malignancies of the peritoneum Epidemiological data regarding peritoneal surface malignancies are very limited; current data are based on individual national cancer registries and international databases. The most comprehensive data are provided by GLOBOCAN 2008 [7] and other local registries of individual peritoneal surface carcinomas. In the Czech Republic, these data have not been analyzed in detail to date, as diagnoses of peritoneal surface malignancies are very rare and are not published annually in national health reports; they are not commonly available to the public or to experts
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