Abstract
BackgroundThe incidence and incidence trends of breast cancer according to molecular subtype are unknown at a population level in France. The registry data enables this study and may give this information, that is crucial to describe and understand breast cancer epidemiology.MethodsWe estimated the incidence rates of breast cancer for each molecular subtype using data from three cancer registries in France for the period from 2007 to 2012. Molecular subtypes were defined with immunohistochemical data. Poisson models were estimated to modelize the course of breast cancer incidence and to test the trends.ResultsThe study included 12,040 patients diagnosed between 2007 and 2012 in the three administrative areas covered by the registries. There was no significant trends in the proportion of each molecular subtype year by year. The age distribution of incident cases was different depending on the molecular subtypes (p < 0.001). The course of incidence between 2007 and 2012 was also different depending on molecular subtype according to the multivariate Poisson model (p < 0.001).ConclusionThe description of incident cases of breast cancer according to molecular subtype at a population level showed differences in trends. The trends in incidence differed according to molecular subtype, and this should improve our understanding of overall changes in incidence. This analysis is important to plan screening and treatment resources at a population level.
Highlights
The incidence and incidence trends of breast cancer according to molecular subtype are unknown at a population level in France
Overall, 12,040 incident cases of breast cancer were included in the three French departments between 2007 and 2012 (Table 1)
This study aimed to describe the trends in incidence and distribution among age classes of breast cancers by molecular subtypes
Summary
The incidence and incidence trends of breast cancer according to molecular subtype are unknown at a population level in France. The registry data enables this study and may give this information, that is crucial to describe and understand breast cancer epidemiology. Breast cancer is the most frequent cancer in women in France [1]. Trends in incidence are well described [1], explanations for these trends are lacking. Epidemiological studies have failed to propose explanations for observed trends in breast cancer incidence. Help may be at hand from biological researchers. There is still few population-based epidemiological studies on this subject, since immunohistochemical characteristics are rarely available at a population level.
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