Abstract
BackgroundPsoriasis is associated with an atherogenic lipid profile but longitudinal changes in lipids around disease onset are unknown. The purpose of our study is to examine the effect of psoriasis onset on serum lipid profiles.MethodsWe compared changes in lipid profiles in a population based incident cohort of 689 patients with psoriasis and 717 non-psoriasis subjects. All lipid measures performed 5 years before and after psoriasis incidence/index date were abstracted. Random-effects models adjusting for age, sex and calendar year were used to examine trends in lipid profiles.ResultsThere were significant declines in total cholesterol (TC) and low-density lipoprotein (LDL) levels during the 5 years before and after psoriasis incidence/index date in both the psoriasis and the non-psoriasis cohorts, with a greater decrease noted in the TC levels (p=0.022) and LDL (p=0.054) in the non-psoriasis cohort. High-density lipoprotein (HDL) levels increased significantly both before and after psoriasis incidence date in the psoriasis cohort. Triglyceride (TG) levels were significantly higher (p<0.001), and HDL levels significantly lower (p=0.013) in patients with psoriasis compared to non-psoriasis subjects. There were no differences in prescriptions for lipid lowering drugs between the two cohorts.ConclusionsPatients with psoriasis had a significant decrease in TC and LDL levels during the 5 years before psoriasis incidence. Higher mean TG and lower mean HDL levels were noted in the 5 years before psoriasis incidence. These changes are unlikely to be caused by lipid lowering treatment alone and require further exploration.
Highlights
Psoriasis is associated with an atherogenic lipid profile but longitudinal changes in lipids around disease onset are unknown
There were significant declines in total cholesterol (TC) and low-density lipoprotein (LDL) levels during the 5 years before and the 5 years after psoriasis incidence/index date in both the psoriasis and the non-psoriasis cohorts with a greater decrease noted in the TC levels and LDL in the non-psoriasis cohort
The data from our study show that there is a downward trend in TC and LDL in both populations in the five years before psoriasis incidence/index date, the decline in TC and LDL levels was smaller in the psoriasis patients than in the non-psoriasis subjects
Summary
Psoriasis is associated with an atherogenic lipid profile but longitudinal changes in lipids around disease onset are unknown. The purpose of our study is to examine the effect of psoriasis onset on serum lipid profiles. Among the comorbidities which predispose patients with psoriasis to increased risk of CV disease are psoriatic arthritis and sleep disorders [3], as well as other traditional risk factors for CV disease, including atherogenic lipid profiles [4,5]. To address the relationship between psoriasis and the profile of potentially atherogenic lipids, we performed a longitudinal study of changes in lipid profile during the period surrounding psoriasis incidence in a populationbased cohort of patients with psoriasis and a comparison cohort of non-psoriasis subjects. The aim of this study was to determine the effect of psoriasis onset on serum lipid profiles by comparing lipid profiles in patients with psoriasis and non-psoriasis subjects during the 5 years before and 5 years after psoriasis incidence/index date
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