Abstract
Breast cancer (BC) is the top cancer among women worldwide and the most frequent malignancy among Iranian women over the past few decades. The increasing trend and high mortality rate of BC in the developing world necessitates studies concentrating on its characteristics in countries in Asia. The current study focused on clinical and histopathological features of BC among Iranian females. This retrospective study involved 714 Iranian patients with histopathologically proven BC undergoing resection of primary tumours and axillary clearance. Demographic, clinical and histopathological data were obtained and studied between ten year age groups (≤ 40 years, 41-50 years, 51-60 years, 61-70 years, and ≤ 71 years) in four chronologic phases from 1994-2009. Mean age of patients was 49.4 ± 13.1 years. Most of cases (33.2%) were in 41-50 group. Mean size of primary tumors was 3.94 ± 2.47 cm and 87.1% of cases had infiltrative ductal carcinoma. Modified radical mastectomy was the most common method of surgery carried out (48.8%). Some 57.1% of tumors were in pT2 and tumor size decreased significantly during the period (p<0.05). The most common BC stage was llla (27%). Lower BC stages (0 and 1) constituted 13.9% of the diagnosed tumors. Our series of patients aged ≤ 40 had larger tumors (mean 4.73 ≤ 3.02 cm) compared to older age groups (p=0.003). Lower stages (0 and I) were more frequent among the oldest patients while nearly 50% of patients aged ≤ 40 had tumor stage III. We also observed a significant decreasing trend in the mean LN count (p<0.05) and blood vessel invasion (p=0.023) from younger to older age groups. More aggressive disease for younger age groups, earlier peak incidence age and high rate of advanced BC at the time of diagnosis among Iranian women, were the main findings of this study.
Highlights
Breast cancer (BC) is the most common cancer among women worldwide, accounting for 16% of all female cancers and the leading cause of cancer related death in women (Parkin and Fernandez, 2006)
In order to identify variations in tumor characteristics based on age, we investigated association of patient’s age with tumor size, axillary lymph node involvement (ALNI), stage of BC, vascular invasion and histopathological type of the disease
BC is the top cancer in women worldwide and is increasing specially in developing countries, where most of cases are diagnosed in late stages (Agarwal et al, 2007; Mousavi et al, 2008), a finding that is indicated in the current study, as well
Summary
Breast cancer (BC) is the most common cancer among women worldwide, accounting for 16% of all female cancers and the leading cause of cancer related death in women (Parkin and Fernandez, 2006). Due to lack of enough evidences describing age distribution, clinicopathological characteristics and stage of BC in Iran, it is difficult to investigate ongoing and future condition of the disease and consider the best preventive and therapeutic approach to lower the burden of it (Mousavi et al, 2007; Harirchi et al, 2011) Considering this fact along with high mortality rate of BC in developing countries (such as Iran) (Shibuya et al, 2002; Harirchi et al, 2011), it is crucial to organize epidemiological studies with demographic trend analysis concentrating mainly. Conclusions: More aggressive disease for younger age groups, earlier peak incidence age and high rate of advanced BC at the time of diagnosis among Iranian women, were the main findings of this study
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