Abstract
Breast cancer is the most common cancer and the first cause of cancer death in women worldwide, with infiltrating duct carcinoma as the most common morphology. This study aimed to investigate trend of breast cancer incidence by age groups and histological changes in Iranian women between 2003 and 2008. This is analytic study, carried out based on re-analysis of the Cancer Registry Center report of health deputy for women's breast cancer in Iran during a 6-year period (2003-2008). Statistical analysis for incidence time trends and morphology change percentage carried out joinpoint regression analysis using the software Joinpoint Regression Program. A total of 36,340 cases were reported for Iranian women in the six years. Analytical trend showed an increasing incidence trend with significant annual percentage change (APC) of 15.2 (CI: 11.6 to 18.8). The lowest and highest significant increased trend were related to age groups of 40 to 44 years and above 85 years, respectively; with APCs of 13.0 and 25.1, respectively. Of total cases, 78.7% of cases were infiltrating duct carcinoma, decreasing from 82.0% in 2003 to 76.6% in 2008, which was significant with an APC equal to -1.76 (CI:-2.7 to -0.8). The incidence trend of breast cancer is rising in Iranian women. The highest incidence was observed in the age groups 45-65 and 80-85. In conclusion, to reduce breast cancer incidence and its burden, preventive and screening programs for breast cancer, especially in young women, are recommended in Iran.
Highlights
In the 21st century, all countries has encountered with the fundamental problem of cancer, which is the third cause of death in the world and according to estimates of GLOBOCAN, approximately 12.7million new cancer cases and 7.6 million cancer deaths occurred in 2008(Jemal et al, 2011)
The lowest and highest significant increased trend were related to age groups of 40 to 44 years and above 85 years, respectively; with annual percentage change (APC) of 13.0 and 25.1, respectively
Analytical trend based on Joinpoint logarithmic scale showed an increasing incidence trend with significant Annual Percentage Changes (APC) of 15.15 (CI: 11.6 to18.8) (Table1)
Summary
In the 21st century, all countries has encountered with the fundamental problem of cancer, which is the third cause of death in the world and according to estimates of GLOBOCAN, approximately 12.7million new cancer cases and 7.6 million cancer deaths occurred in 2008(Jemal et al, 2011). Almost 60% of all cancer was seen in developing countries (Vakili et al, 2014) and incidence and morphology trend of cancers is changing in the different countries (Jemal et al, 2010; Almasi et al, 2015; Keyghobadi et al, 2015; Rafiemanesh et al, 2015a; Rafiemanesh et al, 2015b; Razi et al, 2015). Breast cancer is the most common cancer and the first cause of cancer death in women worldwide. Breast cancer is the most common cancer and the first cause of cancer death in women worldwide, with infiltrating duct carcinoma as the most common morphology. This study aimed to investigate trend of breast cancer incidence by age groups and histological changes in Iranian women between 2003 and 2008. The lowest and highest significant increased trend were related to age groups of 40 to 44 years and above 85 years, respectively; with APCs of 13.0 and 25.1, respectively. To reduce breast cancer incidence and its burden, preventive and screening programs for breast cancer, especially in young women, are recommended in Iran
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