Abstract
The last few years of enhancing the design of hybrid mesoporous organosilica nanoparticles has allowed their degradation under specific pathologic conditions, which finally is showing a light in their potential use as drug delivery systems towards clinical trials. Nevertheless, the issue of controlling the degradation on-demand at cellular level still remains a major challenge, even if it has lately been addressed through the incorporation of degradable organo-bridged alkoxysilanes into the silica framework. On this basis, this mini review covers some of the most recent examples of different degradable organosilica nanomaterials with potential application in nanomedicine, from degradable non-porous to mesoporous organosilica nanoparticles (MONs), functionalized with responsive molecular gates, and also the very promising degradable periodic mesoporous organosilica materials (PMOs) only consisting of organosilica bridges.
Highlights
The last few years of developing and designing the ideal drug delivery system have faced crucial challenges
The evolution of new administration mechanisms has to different synthetic platforms, silica-based nanomaterials have setNevertheless, a precedent inthis terms deal Among with biodistribution, pharmacokinetics and cell uptake control
The evolution of new administration mechanisms has to deal with a major hurdle in nanomedicine reaching the clinic, and it has become commonly accepted biodistribution, pharmacokinetics and cell uptake
Summary
The last few years of developing and designing the ideal drug delivery system have faced crucial challenges. These prolific materials are known to accomplish many biomedical requirements, such as improved hydrothermal and hydrolytic stability, good colloidal dispersity, adjustable biodegradability, and high loading capacity towards specific drugs, framework-induced stimuli-responsive release behavior, good biocompatibility, and particle sizes in the nanoscale range, all providing more efficient theranostic solutions if chosen the appropriate bridging groups This class of materials can introduce organic functional groups that can be cleaved under specific physiological conditions (for example, if enzymatic degradation features are added via cleavable amide-bridges) or other types of degradable linkers, that lead to the complete disintegration of the silica-based particles (as shown above in Figure 1d) [18,19]. This mini review will highlight the possible post-modification of the surface of degradable MONs with molecular gates, introducing the advantageously controlled cargo transport out of the pores upon applied stimuli, of extreme interest in future theranostic applications [22]
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