Abstract

The biological and medical importance of hydrogen sulfide (H2S) has been recognized for decades. The aim of this bibliometric study is to analyze the quantity and quality of publications in H2S biology and medicine (H2SBM) based on the databases of Web of Science and Google Scholar. A total of 5881 publications published between 1990 and 2016 were analyzed. The number of H2SBM papers published before 2004 was below 100 annually, but thereafter this number rapidly increased and peaked in 2015 with more than 7-fold increase. All publications related to H2SBM research achieved a total h-index of 136 and were cited 123,074 times. The most published disciplines in H2S biomedicine research were the cardiovascular system (8.5%), neuroscience (6.5%), and gastroenterology hepatology (4.7%). The country with the greatest number of publications in the H2SBM research field was the USA with 1765 (30.0%) publications, followed by China with 995 (16.9%) publications and Japan with 555 (9.4%) publications. The top 3 most published institutes were National University of Singapore, Peking University in China, and University of Groningen in Netherlands. Nitric Oxide Biology and Chemistry was the most exploited journal for H2SBM publications with 461 articles, followed by FASEB Journal with 200 publications and Antioxidants Redox Signaling with 116 publications. The most highly cited publications and researchers in H2SBM research were also unmasked from this bibliometric analysis. Collectively, H2SBM publications exhibit a continuous trend of increase, reflecting the increased H2SBM research intensity and diversity globally.

Highlights

  • Hydrogen sulfide (H2 S) was historically considered to be highly toxic and hazardous to the environment

  • Four international conferences on the Biology and Medicine of H2 S have been held in Shanghai (China, 2009), Atlanta, GA (USA, 2012), Kyoto (Japan, 2014), and Naples (Italy, 2016) [12,13,14], and the 5th international conference will be held in Toronto, ON (Canada) in 2018

  • From 1990 to 2003, the H2 S biology and medicine (H2 SBM) scientific literature was in a steady-state

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Summary

Introduction

Hydrogen sulfide (H2 S) was historically considered to be highly toxic and hazardous to the environment. The concept of gasotransmitter and the classifying criteria were first framed in 2002, and since we have witnessed the rapid growth of the research field in H2 S biology and medicine (H2 SBM) [2,11]. A large amount of work has been conducted globally leading to many breakthrough discoveries on the paramount roles of H2 S in biology and medicine. Four international conferences on the Biology and Medicine of H2 S have been held in Shanghai (China, 2009), Atlanta, GA (USA, 2012), Kyoto (Japan, 2014), and Naples (Italy, 2016) [12,13,14], and the 5th international conference will be held in Toronto, ON (Canada) in 2018.

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