Abstract
Objective: In this study, we evaluated treatment volume determination with PET-CT fusion for small cell lung cancer. Materials and methods: Primary goal of this study has been to evaluate treatment volume determination for fused PET-CT in patients with small cell lung cancer. We have carried out a comparative analysis of treatment volume determination by CT simulation images only or by integration of PET. While we primarily focused on evaluation of incorporated multimodality imaging for treatment volume determination, we also assessed critical organ contouring along with interobserver and intraobserver variations. Ground truth target volume has been utilized for comparative analysis, and it was determined by board certified radiation oncologists after detailed evaluation of all imaging and relevant data with thorough colleague peer review and consensus.
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