Abstract
Stroke that occurs during sleep (ie, wake-up stroke) accounts for around 20% of acute stroke presentations, and treatment options were sparse until recently, because symptom onset time is unknown. Observational findings suggest that symptom onset might occur shortly before waking, possibly placing some patients within the conventional time window for thrombolysis or thrombectomy. Clinical trials1–3 have shown a benefit from reperfusion when selecting patients with advanced imaging methods, such as MRI or CT perfusion.
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