Abstract
We would like to thank for the interest for the article and comments in the response. We believe that cell therapy may offer a treatment for severe voice problems in patients with vocal fold scarring and MSC treatment is a valuable alternative.
Highlights
Commentary The main aim of the study was safety aspects of the MSC treatment, and we found no side effects or complications after the treatment
* Correspondence: Stellan.Hertegard@ki.se 1Department of Clinical Sciences and Intervention, Karolinska Institutet, Stockholm, Sweden 2Department of Otorhinolaryngology, Karolinska University Hospital Huddinge, S-141 86 Stockholm, Sweden Full list of author information is available at the end of the article worldwide, without reported side effects
We chose this procedure because all our animal studies preceding the clinical human trial showed positive results regarding healing, inflammatory response, and functional result, both in “acute” damage model and after resecting present scar tissue [4–8]
Summary
We would like to thank for the interest for the article and comments in the response. The 3 patients which were previously treated for laryngeal cancer (all at least 15 years before MSC treatment) have so far been followed between 5 and 7 years. Autologous (and allogeneic) MSCs have been administered, as local injection or intravenous infusion, to > 10,000 patients
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