Commentary about mesenchymal stem cells and scarred vocal folds

Alexia Mattei,Florence Sabatier,Mélanie Velier,Antoine Giovanni,Jérémy Magalon,Françoise Dignat-George

doi:10.1186/s13287-020-01693-9

Abstract

A commentary to “Hertegård, S., Nagubothu, S.R., Malmström, E. et al. Treatment of vocal fold scarring with autologous bone marrow-derived human mesenchymal stromal cells - first phase I/II human clinical study. Stem Cell Res Ther 11, 128 (2020)” concerning the surgical intervention including a scar resection, the use of the Voice Handicap Index, the surgical and regulatory points of view regarding the inclusion of patients with laryngeal carcinomas history, and the side effects of bone marrow harvesting.

Highlights

Main text We have read with great interest the article by Hertegård et al entitled “Treatment of vocal fold scarring with autologous bone marrow-derived human mesenchymal stromal cells - first phase I / II human clinical study” [1]
We would like to congratulate the authors of this clinical trial which highlights the anti-fibrotic potential of cellbased therapy using mesenchymal stem cells (MSC) and brings hope in the difficult treatment of scar vocal folds
Resection of scar tissue is one of the. This comment refers to the article available at https://doi.org/10.1186/ s13287-020-01632-8. * Correspondence: alexia.mattei@laposte.net; alexia.mattei@ap-hm.fr 1Department of Oto-Rhino-Laryngology and Head and Neck Surgery, APHM, Assistance Publique-Hôpitaux de Marseille, La Conception University Hospital, 147 bd baille, 13385 Marseille Cedex, France 2Aix Marseille Univ, CNRS, LPL, Aix-en-Provence, France Full list of author information is available at the end of the article potential treatments offered in this type of disease

Summary

Introduction

We have read with great interest the article by Hertegård et al entitled “Treatment of vocal fold scarring with autologous bone marrow-derived human mesenchymal stromal cells - first phase I / II human clinical study” [1]. Main text We have read with great interest the article by Hertegård et al entitled “Treatment of vocal fold scarring with autologous bone marrow-derived human mesenchymal stromal cells - first phase I / II human clinical study” [1].

Results

Conclusion