Treatment of sudden deafness with type 2 diabetesmellitus by post-auricular subperiosteal injection of methylprednisolone

Abstract

Objective:To investigate the therapeutic effect of post-auricular subperiosteal injection of methylprednisolone combined with ginkgo biloba injection and mouse nerve growth factor in sudden deafness with type 2 diabetesmellitus. To understand the effect of post-auricular subperiosteal injection of methylprednisolone on type 2 diabetesmellitus complicated with sudden deafness and its effect on blood-glucose level, and to explore a more effective and safe method for treating this special group of sudden deafness. Method: Total 84 patients suffered from type 2 diabetesmellitus with sudden deafness and treated in Shaanxi Provincial People's Hospital from March 2017 to June 2018 were randomly divided into experimental group(post-auricular subperiosteal injection of methylprednisolone+ginkgo biloba injection, mouse nerve growth factor)(n=48) and a control group(ginkgo biloba injection, mouse nerve growth factor)(n=36). Each group was divided into high frequency, low frequency and flat and total deafness group. Then to compare the clinical efficacy of the two groups and the difference of the fluctuation of blood glucose and HbA1c before treatment and 2 hours after treatment. Result:①The effective rate of treatment in the experimental group was 79.17%, higher than that in the control group(58.33%), P<0.05. The results indicated that the effect of post-auricular subperiosteal injection of methylprednisolone combined with ginkgo biloba injection and mouse nerve growth factor was effective in sudden deafness with type 2 diabetesmellitus. ②There was no significant difference in the fluctuation of blood glucose and HbA1c before treatment and 2 hours after treatment in the experimental group, and it indicated that this treatment can effectively avoid systemic side effects of steroid and ensure the safety of the treatment. Conclusion:Post-auricular subperiosteal injection of methylprednisolone combined with ginkgo biloba injection and mouse nerve growth factor is effective in patients with sudden deafness with type 2 diabetesmellitus, furthermore, blood glucose will not be affected by the using of steroid, and it will aviod systemic hormonal side effects.