Safety and efficacy of hormone therapy in the treatment of sudden deafness

Abstract

Objective To evaluate the safety and clinical efficacy of hormone therapy in the treatment of sudden deafness. Methods Eighty hospitalized patients(100 ears) with sudden deafness were randomly divided into two groups. The patients in the control group were treated with batroxobin, and the patients in the experimental group were treated with batroxobin and dexamethasone. The hearing increased value of each frequency, the overall treatment effect, hemodynamics before and after treatment, coagulation and drug adverse reaction between the two groups were compared. Results The hearing increased value of 250, 500, 1 000 and 2 000 Hz frequency in the experimental group were significantly higher than those in the control group; after treatment, the levels of fibrinogen, plasma viscosity, whole blood viscosity and platelet factor in the experimental group were significantly lower than those in the control group; the prothrombin time, activated partial thromboplastin time and prothrombin time were significantly higher than those in the control group, the differences were significant(all P 0.05). Conclusions The curative effect of hormone therapy on sudden deafness is significant and the safety is high. Key words: Hormone; Sudden deafness; Clinical efficacy; Safety