Abstract
Polycystic ovary syndrome (PCOS) is a common disorder of women in reproductive age characterized by clinical and biochemical disorders, and it´s main symptoms might appear from adolescnce. PCOS (polycystic ovary syndrome) is characterized by menstrual disorders (amenorrhea or oligomenorrhea), anovulation, hyperandrogenism and polycystic change of ovaries. Insulin-resistant hyperinsulinism is an important extrinsic factor in the steroidogenic dysregulation of PCOS and lowers the treatment of ovulation. I investigate the relation between hyperinsulinemia and PCOS and the effect of metformin, insulin sensitizer in treatment of PCOS by case-control study of 30 patients with clomiphene citrate-resistant PCOS and 30 women with regular menstrual cycles. Patients with PCOS had hyperinsulinemia compared with control group significantly. The ovulation rate of laparoscopic ovarian drilling plus metformin therapy was 95.5% (21/22).
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