Abstract
Isolation perfusion chemotherapy for osteosarcoma in the extremities has been performed on 111 cases since 1960 in our department.Our therapeutic regimen consisted of perfusion chemotherapy and amputation in the first group of 17 cases between 1960 an 1964, perfusion chemotherapy, amputation and bronchial arterial infusion in the second group of 48 cases between 1965 and 1972, and perfusion chemotherapy, amputation and systemic administration of adriamycin in the third group of 19 cases between 1973 and 1978.Five years survival rate of the first group is 38.0% and that of the second group is 35.1%.Four years survival rate of the third group is 59.8%.Recently we have performed perfusion chemotherapy, amputation and systemic administration of vincristine, high dose methotrexate with citroforum factor rescue and adriamycin in the treatment of osteosarcoma.
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