A radomized trial of bronchial arterial infusion(BAI), traditional vein chemotherapy and BAI plus vein chemotherapy sequential therapy in the treatment of advanced and late NSCLC.

Abstract

Many patients always late disease when they diagnozed with lung cancer, the therapeutic effect of late lung-cancer was very poor, the aim of this study is to compare therapeutic effect among bronchial arterial infusion (BAI), traditional vein chemotherapy and BAI plus vein chemotherapy sequential therapy, for late NSCLC, and find a better way to treat late lung cancer. One hundred and seven patients with advanced NSCLC were randomly treated by BAI, traditional vein chemotherapy and BAI plus vein chemotherapy sequential therapy. Primary lesion's total response rate(RR) of BAI group, traditional vein chemotherapy group and sequential therapy group were: 59.22%,30.23% and 69.05%, respectively. RR of primary lesion in BAI group was significantly higher than that in traditional vein chemotherapy group(P <0.01), sequential therapy group was much higher than that in traditional vein chemotherapy group(P <0.01), there was no differences between BAI group and sequential therapy group(P >0.05). Metastasis's total response rate(RR) in BAI group, traditional vein chemotherapy group and sequential therapy group were: 18.19%, 53.58%,60.00%, respectively. RR in metastasis BAI group was significantly lower than that in traditional vein chemotherapy group(P <0.05), sequential therapy group was much higher than that in BAI group(P <0.01), there was no remarkable differences between traditional vein chemotherapy group and sequential therapy group(P >0.05). BAI plus vein chemotherapy sequential therapy has good response on both NSCLC primary lesion and metastasis.