Treatment of intracranial hemanyiopericytoma with three-dimensional conformal radiotherapy combined with stereotactic radiosurgery

Abstract

Objective To evaluate the effect of three-dimensional conformal radiotherapy (3D-CRT) combined with stereotactic radiosurgery (SRS) on central nervous system hemanyiopericytoma (HPC) after the excision surgery.Methods The clinical manifestations,pathological characteristics,imaging features and treatment efficacy of HPC were analyzed retrospectively by examining the data of 6 patients with HPC after partial resection in our hospital from October 1,2008 to November 30,2011.Results Age of the HPC patients ranged from 33 to 55 years (median 46.5 years).The main clinical manifestations included intracranial hypertension and focal symptoms caused by tumor oppression and destruction of the surrounding tissue.Pathological staining showed intensive tumor cells with spindle or polygonal shapes; the cell membrane was unclear; the cytoplasm was slightly eosinophilic; nuclear atypia and nuclear fission were visible.Follow up was performed in all the patients with 1 periods ranged from 14 to 44 months,showing 2 patients achieved complete remission and 4 partial remission.Conclusion HPC is an infrequent tumor of the central nervous system and has tendencies of recurrence and metastasis; Surgical resection is the best treatment; for the patients after partial resection,3D-CRTcombined with SRS is likely to further improve the therapeutic effect. Key words: Hemanyiopericytoma; Three-dimensional conformal radiotherapy; Stereotactic radiosurgery