Abstract
To determine the clinical and parasitological response to treatment of intestinal microsporidiosis with albendazole. Open prospective study. Hospital-based HIV/genito-urinary medicine unit. Six consecutive AIDS patients with small intestinal microsporidiosis as the only identified cause of diarrhoea after intensive gastrointestinal investigations. Diarrhoea resolved completely in all patients within 1 week of starting treatment, and body weight stabilized or increased. Four patients who relapsed at 19-31 days after the cessation of treatment responded to a second course of albendazole. Degenerative changes occurred in the parasites after treatment, which had not been seen either in pre-treatment biopsies or, in four patients, following therapy with other drugs. Albenazole is a useful palliative treatment for microsporidial diarrhoea.
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