Treatment of Hypothyroidism with Flavonoid Rich Extract of Fucus vesiculosus L Algae in Adult Rats

Abstract

Background: Thyroid-related diseases, such as hypothyroidism, affect large populations worldwide and have severe health effects. Fucus vesiculosus L seaweed, which is full of iodine and other biologically active ingredients, has always been recognized as a remedy for hypothyroidism. The objective of this study was to explore the effects of a flavonoid extract of the algae, Fucus vesiculosus L, on the thyroid hormones in rat. Method: Thirty-two mature rats were separated into four categories and given different amounts of the seaweed extract over the span of a month. Blood samples were then taken and assessed for thyroid hormones, antioxidants, and liver enzymes. The effect of the flavonoid extract of the Fucus vesica algae on thyroid hormones in the serum of adult rats was studied, by estimation thyroid hormones, glutathione peroxidase, and peroxynitrite, in addition to liver enzymes in the blood serum of (32) adult rats. Results: The results showed that the TSH level a significant decrease in all groups compared to the control group after a month of dosing. T3 also showed a significant increase in all groups compared to the control, in addition to T4, which showed a significant increase in all groups. As for the level of glutathione peroxidase, it showed a significant decrease in all groups compared to the control group, while peroxynitrite showed a significant decrease in all groups compared to the control group. As for liver enzymes, they showed a significant decrease in all groups compared with the control group. Conclsuion: In summary, the Fucus vesiculosus L. seaweed flavonoid extracts showed a marked deviations in the concentrations of thyroid hormones and exposed potential hepato-protective and antioxidative activity in adult rats.