Abstract
The penicillin era of the treatment of infections due to Neisseria gonorrhoeae began in 1943, when Mahoney et al.1 demonstrated that penicillin was effective in the treatment of gonococcal urethritis in men. They gave their patients a total of 160,000 units of penicillin sodium in divided doses. Penicillin, when it became generally available in the late 1940's, rapidly became the drug of choice for the treatment of gonorrhea.Over the ensuing three decades, clinical isolates of N. gonorrhoeae gradually became more resistant to the action of penicillin.2 There are two basic mechanisms by which a micro-organism may become resistant to . . .
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