TREATMENT OF GINGIVAL RECESSION DEFECT USING MESENCHYMAL STEM CELLS CULTURED PCL BASED BONE REGENERATING SCAFFOLD: A RANDOMIZED CONTROLLED CLINICAL STUDY

Abstract

Gingival recession defects generally give rise to functional as well as aesthetic problems. Basic periodontal treatment could only get rid of plaque and calculus to control inflammation, while the ultimate goal of periodontal treatment is to repair and reconstruct the periodontal lining using a gum grafting periodontal plastic surgery. So far, use of stem cells has proven to be effective for in vivo periodontal regeneration and repair of structural defects in case of Miller’s classification class I. However, class II and class III required serious bone grafting to repair the defect.
 In the present study, a patient of multiple gingival recession (Miller’s class II) was treated using human Umbilical Cord Wharton’s jelly derived mesenchymal stem cells (hUCMSCs) in combination with bone regeneration poly ε-caprolactone (PCL)-graphene oxide (GO)-Cissus quadrangularis(CQ)(PCL-GO-CQ) scaffold. The study was concluded with reference to clinical parameters including root coverage that was recorded at baseline, and at 2 months postoperative. The final analysis revealed significant reduction of gingival recession with over 70% of root coverage. Thus, the study proved the efficacy of bone regenerating scaffold to regenerate multiple tissue defects, when seeded with human Umbilical cord Wharton’s jelly derived mesenchymal stem cells.