Treatment of gingival recession defect using human umbilical cord mesenchymal stem cells cultured on PCL based bone regenerating scaffold: a randomized controlled clinical study

Abstract

Background & Aim Gingival recession defects generally give rise to functional as well as aesthetic problems. Basic periodontal treatment can only remove plaque and calculus to control inflammation, while the final goal of periodontal treatment is to repair and reconstruct the periodontal tissue using a gum grafting periodontal plastic surgery. Use of stem cell for in vitro periodontal regeneration to repair defects is effective in Miller's classification class I. However, class II and III required serious bone grafting to repair the defect. Methods, Results & Conclusion In present study, a patient of multiple gingival recession (Miller's Class II) was selected for treatment using human umbilical cord derived mesenchymal stem cells in combination with bone regeneration PCL scaffold. Clinical parameters including gingival recession, probing pocket depth, clinical attachment level, and width of keratinized gingiva were recorded at baseline, and at 6 months postoperative. Six months post surgery, significant reduction of gingival recession indicating over 80% root coverage was observed. Thus proving the efficacy of bone regenerating scaffold along with mesenchymal stem cells from Wharton's Jelly part of human umbilical cord.