Abstract
Dopamine receptor blockade drugs results in substantial with neuroleptic amelioration of schizophrenic delusions and hallucinations. The dopamine hypothesis, based primarily on a correlation between these antipsychotic effects of neuroleptics and their dopamine blocking propensity, has been the predominant biochemical theory of schizophrenia (Snyder 1976). However, a significant number of chronic schizophrenic patients manifest prominent negative features, such as blunted affect, psychomotor retardation, apathy, and social withdrawal, which respond poorly to neuroleptic medication (Andreasen and Olsen 1982). There is evidence linking chronic schizophrenia to abnormalities of serotonergic function (e.g., DeLisi et al. 1981), including reports of increased plasma (Garelis et al. 1975; DeLisi et al. 1981; Freedman et al. 1981) and platelet (Jackman et al. 1983) serotonin concentration and a possible relationship to cortical atrophy (DeLisi et al. 1981). Furthermore, a preliminary trial with ritanserin, an experimental serotonin @-IT,) receptor blocker,
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