Abstract
Purpose of the study: Chronic invasive fungal sinusitis is a rare condition, and the conventional treatment surgical debridement and systemic antifungal therapy such as amphotericin B. Recently, voriconazole has demonstrated superior efficacy in the treatment of invasive aspergillosis, compared to amphotericin B. However, its use in invasive fungal sinusitis in an HIV patient has not been reported. Supplement: Abstracts of the Tenth International Congress on Drug Therapy in HIV Infection http://www.biomedcentral.com/content/pdf/1758-2652-13-S4-info.pdf Conference: Tenth International Congress on Drug Therapy in HIV Infection 7-11 November 2010 Glasgow, UK (Published: 8 November 2010) doi:10.1186/1758-2652-13-S4-P190 Cite this article as: Ho et al.: Treatment of chronic invasive fungal sinusitis with voriconazole in an HIV patient. Journal of the International AIDS Society 2010 13(Suppl 4):P190. Full text: PubMed Central: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3112972/
Highlights
We describe a case of chronic invasive fungal sinusitis in a patient with HIV infection successfully treated with surgical clearance and a prolonged course of oral voriconazole
Summary of results A 39 year old Malawian lady presented to the Ear, Nose and Throat (ENT) surgeons with recurrent nasal polyps and was noted to have proptosis in April 2009
Grocott staining of biopsy specimen demonstrated presence of fungal hyphae, and tissue culture grew Aspergillus flavus
Summary
Treatment of chronic invasive fungal sinusitis with voriconazole in an HIV patient. From Tenth International Congress on Drug Therapy in HIV Infection Glasgow, UK. Purpose of the study Chronic invasive fungal sinusitis is a rare condition, and the conventional treatment surgical debridement and systemic antifungal therapy such as amphotericin B. Voriconazole has demonstrated superior efficacy in the treatment of invasive aspergillosis, compared to amphotericin B. Its use in invasive fungal sinusitis in an HIV patient has not been reported
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