Abstract
Adult intestinal stem cells (ISCs) reside at the crypt base, where they continuously proliferate to maintain homeostasis of the intestinal epithelium. As a result of a lifetime of cell division, these LGR5+ ISCs face the combined risk of genomic mutations and telomere attrition. In this issue of EMBOJ , [Schepers et al (2011)][1] examine whether ISCs employ telomerase expression and asymmetric chromosome segregation to protect their genome. [1]: #ref-9
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