Transvenous Radiofrequency Ablation of Adrenal Gland: Experimental Study.

Abstract

The aim was to evaluate a flexible device for transvenous adrenal gland radiofrequency ablation in vitro and in an in vivo animal model. A flexible radiofrequency-tip catheter with an inner-cooling mechanism and a guidewire lumen was made. Then, using a polyvinyl alcohol gel model, the ablation diameter was evaluated and how much energy to deliver in vivo was determined. Finally, transvenous radiofrequency ablation of the left adrenal glands of two pigs was performed, delivering 5000 or 7000J in a single dose to each. The ablation effects were also assessed by histological examination of hematoxylin-eosin-stained sections. The mean ablation diameters in the gel model were 20.2 and 21.9mm in the short axis and 15 and 20mm in the long axis for 5000 or 7000J, respectively. The device was inserted into porcine left adrenal vein with no complications. The mean ablation diameters were 10mm in the shorter axis (whole thickness of porcine left adrenal gland) in the porcine model for 7000J. Transient increases in blood pressure and heart rate occurred during ablation. Histologically, the adrenal gland showed severe necrosis at ablated area. There was venous congestion upstream in a non-ablated area, and thermal damage to surrounding organs was not observed. A flexible radiofrequency-tip catheter could be inserted successfully into the left adrenal vein. The left adrenal gland was entirely ablated without any thermal damage to surrounding organs. We suggest transvenous adrenal ablation has potential as a therapeutic option for primary aldosteronism.