Abstract

Background: Biofilm formation is considered to be one of reasons for difficultyin theprevention and control of Streptococcus suis. Aims: To explore the potential genes involved in the biofilm formation of S. suis. Methods: Transposon mutagenesis technology was used to screen biofilm-defective strains of S. suis, and the potential genes related to biofilm were identified. Results: A total of19 genes were identified thatwere involved in bacterial metabolism, peptidoglycan-binding protein, cell wall synthesis, ABC transporters, and so on. Conclusion: This study constructed 979 transposon mutation libraries of S.suis. A total of19 gene loci related to the formation of S. suis biofilm were identified, providing a reference for exploring the mechanism of S.suis biofilm formation in the future.

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