Abstract
Background The Transmission Disequilibrium Test (TDT) is a well established family-based test for genetic association. The advantage of TDT over population-based association studies test, which is protected against population stratification, and hence, an association finding can be attributed to the presence of linkage. Quantitative traits (QT) are more informative on within-genotype variability and hence, statistical tests for identifying genes based on such traits tend to be more powerful compared to binary or qualitative traits. The TDT is based on a trio design (two parents and one offspring per family). However, if multiple sibs are present, TDT is only a valid test for linkage. In our study, we have extended the test for quantitative traits based on families with multiple offspring using a logistic regression framework.
Highlights
The Transmission Disequilibrium Test (TDT) is a well established family-based test for genetic association
Transmission Disequilibrium Test for quantitative traits based on multiple sibs Hemant S Kulkarni*, Saurabh Ghosh
We have extended the test for quantitative traits based on families with multiple offspring using a logistic regression framework
Summary
Transmission Disequilibrium Test for quantitative traits based on multiple sibs Hemant S Kulkarni*, Saurabh Ghosh. From International Conference on Human Genetics and 39th Annual Meeting of the Indian Society of Human Genetics (ISHG) Ahmadabad, India. From International Conference on Human Genetics and 39th Annual Meeting of the Indian Society of Human Genetics (ISHG) Ahmadabad, India. 23-25 January 2013
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