Abstract
ABSTRACT.The transmissible spongiform encephalopathies are comprised of a group of human syndromes including kuru, an endemic disease of the Fore tribe in Papua, New Guinea; Creutzfeldt-Jakob disease (CJD), a rare, sporadic, pre-senile encephalopathy; and Gerstmann-Straussler-Scheinker syndrome (GSS), which resembles kuru and CJD but is genetically transmissible; as well as scrapie, visna, bovine spongiform encephalopathy (BSE), and transmissible mink encephalopathy (TME) among others in animals. While reference to the animal encephalopathies may be made, the scope of this paper will address the human varieties with a particular focus on Creutzfeldt-Jakob disease.Until recently, CJD, kuru, and GSS were included with subacute sclerosing panencephalitis (SSPE), progressive rubella panencephalitis, and progressive multifocal leukoencephalopathy in the category of slow virus infections. While the latter of these diseases have all been attributed to classic viruses that have been visualized by electron microsc...
Published Version
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