Abstract
Translational Pancreatology. New Approaches in the Development of Novel Biomarkers as Screening Methodologies for Pancreatic Cancer
Highlights
Pancreatic Ductal Adenocarcinoma (PDAC) is the predominant histologic type of pancreatic cancer (PC) and has one of the worse prognoses of all types of cancer leading to 227,000 deaths annually worldwide
This review summarizes recent advances in effective screening for early diagnosis of PDAC using novel molecular biomarkers discovered from various studies including protein biomarkers, mutant DNA templates identified in the circulation in blood samples, DNA promoter hypermethylation and measurement of microRNA as other possible noninvasive biomarker for early detection of Pancreatic Cancer
There are three recognized precursors of invasive ductal adenocarcinoma: Pancreatic Intraephitelial Neoplasia (PanIN), Intraductal Papillary Mucinous Neoplasm (IPMN) and mucinous cystic neoplasm (MCN)
Summary
Translational Pancreatology. New Approaches in the Development of Novel Biomarkers as Screening Methodologies for Pancreatic Cancer. Institute of Biochemistry and Molecular Medicine (CONICET), School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
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