Translating knowledge and raising awareness of Immunology related human disease mechanisms via engagement with the general public and lay audience

Abstract

Abstract Acute rheumatic fever (ARF) is an autoimmune condition caused by untreated Group A Streptococcal (GAS) infection of the upper respiratory tract (and possibly skin). Multiple or severe attacks of ARF can cause cardiac damage known as rheumatic heart disease (RHD). Effective management for ARF requires painful monthly intramuscular injections of Benzathine Penicillin G (BPG) known as secondary prophylaxis. The goal of secondary prophylaxis is to prevent GAS infections that may lead to the recurrence of ARF. Rates of adherence to secondary prophylaxis are usually low due to the frequency and duration of injection, pain and access to proper and timely healthcare. A less painful and longer acting BPG formulation is urgently needed. Research being undertaken in New Zealand seeks to support global BPG reformulation efforts. The purpose of this work was to support knowledge translation of BPG reformulation research efforts and the associated fundamental Immunology concepts within a public setting. A general public and lay audience outreach event was held through the local university, inviting members of the public to attend. A presentation by a female Pacific Biomedical scientist was offered to support increased knowledge and awareness of emergent rheumatic fever related issues locally and internationally. This event was well attended by the general public. Questions from the audience relating to ARF/RHD dominated, with strong interest expressed in the global efforts to reformulate Penicillin. Additional positive verbal and written feedback was received from those in attendance. This public outreach engagement event supported communication of research findings that was culturally appropriate, clear and meaningful.