Transitional Forms of Langerhans Cell Granules in Letterer-siwe Disease

Abstract

Recently, Langerhans cell granules have been observed not only in the Langerhans cell of normal human epidermis, but also in the histiocytes of Letterer-Siwe disease. The fact that the same Langerhans cell granules have been observed in such unrelated material has aroused interest and led to various speculations regarding their mode of formation.Biopsy specimens were obtained from the left cervical lymph node (Figs. II, III) of a 17 month old Japanese boy. Autopsy specimens were obtained 19 days later from a left cervical lymph node, spleen (Fig. I), liver (Fig. IV), thymus, and skin.