Abstract
Five complexes of Mn(II), Co(II), Ni(II), Cu(II) and Zn(II) with non-steroidal anti-inflammatory drug, flufenamic acid were synthesized: (1) [Mn3(fluf)6EtOH)(H2O)]·3EtOH; (2) [Co(fluf)2(EtOH)(H2O)]·H2O; (3) [Ni(fluf)2(EtOH)(H2O)]·H2O; (4) [Cu(fluf)2·H2O]; (5) [Zn(fluf)2·H2O]. All complexes were characterized by elemental analysis (EA), flame atomic absorption spectrometry (FAAS), Fourier-transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). The crystal structure of 1 was determined by the single crystal X-ray diffraction technique. It crystallizes in the triclinic space group P with three independent Mn(II) cations, six coordinated flufenamato ligands augmented with water and ethanol molecules in the inner coordination sphere. In this crystal, manganese atoms are multiplied by symmetry and form infinite, polymeric chains which extend along the [001] dimension. The Hirshfeld Surface analysis revealed changes in interaction assemblies around all metal centers. The antioxidant and antimicrobial activities were established for all complexes and free ligand for comparison. All compounds exhibit good or moderate bioactivity against Gram-positive bacteria and yeasts.
Highlights
Coordination polymers (CPs) have attracted attention of numerous scientists, and material engineers well over 30 years [1]
In thisHeavy contribution, we report with synthesis, spectroscopic characterization thermal It behavior recognized coordination of metal with ions with substances improve of Mn, Co, that
Antioxidant and antimicrobial activities are air stable at roomwith temperature. They are highly soluble in polar organic of allCompounds investigated 1–5 compounds augmented those of free flufenamic acid were determined
Summary
Coordination polymers (CPs) have attracted attention of numerous scientists, and material engineers well over 30 years [1]. The oldest known CP is the Prussian blue (Fe4 [Fe(CN)6 ]3H2 O) which, since the pioneering work of Keggin and Miles [2], initiated remarkable development in the field [3,4]. Progress in the efficient synthesis and design of CPs [7,8] prompted diverse applications in technologies crucial for civilization development. The gas and energy storage [9,10], intelligent drug delivery [11], production of smart catalysts and recent, remarkable advancements in tunable catalysis are among the most important of these applications [12,13]
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